What makes intestinal failure such a devastating condition? Many intestinal failure patients require parenteral support up to seven days a week, and sometimes for 20 or more hours per day. Intestinal failure in MVID and SBS-IF patients remains a serious unmet medical need. Given the lethal natural history of parenteral support treatment, crofelemer can potentially extend the lives of MVID and SBS-IF patients by reducing their required volume of parenteral support. What are the advantages of the botanical drug development pathway?