The results indicated that these patients had significantly more severe clinical profiles than women with endometriosis without adenomyosis. In the cohort analyzed, 57% were concentrated in the groups with the highest symptom burden, characterized by severe pain, gastrointestinal symptoms, and emotional distress. When both diseases coexist, we observe a greater concentration of patients in the most severe profiles,” explains Dr. Koller. In addition to identifying different symptom patterns, the study assessed how these profiles relate to patients’ quality of life. The most severe profiles had poorer outcomes across nearly every dimension assessed, from functional ability to mental health.