Instanz: TeilenTeilen:Asthma: New Mechanism of Action Curbs Inflammatory ResponseBritta Weller Presse- und ÖffentlichkeitsarbeitForschungszentrum Borstel, Leibniz Lungenzentrum21.07.2026 11:01A team from the University of Bonn and the Research Center Borstel, Leibniz Lung Center (FZB) has discovered a previously unknown mechanism of action for a synthetic peptide that mitigates excessive inflammatory responses in allergic asthma. This mechanism specifically inhibits a key inflammatory switch in the immune system and opens up new avenues for treating chronic inflammatory diseases. The complex mechanism of NLRP3 inflammasome activation was examined step by step to identify the peptide’s targets. “The NLRP3 inflammasome plays a role in a whole range of age-related chronic inflammatory diseases, such as cardiovascular diseases, neuroinflammation, and chronic inflammatory bowel diseases. Additional support was provided by the Leibniz Research Alliance “Leibniz Health Technologies” and the German National Academic Foundation.