In people found to be at elevated risk, the model detected warning signs as much as 15 years before disease onset. ...Cardiovascular disease is still the leading cause of death worldwide, responsible for an estimated 19.8 million deaths in 2022. Doctors typically judge a patient's risk using factors such as age, blood pressure and smoking history. Together, these molecules can reveal early shifts in immune activity, metabolism and blood vessel health before any symptoms show up. AI-based multiomics profiling reveals complementary omics contributions to personalized prediction of cardiovascular disease.