The long-term effects, which may emerge only after years of treatment, are often overlooked or not discussed. When it comes to antipsychotics, these effects are well documented in the literature and include dyslipidemia, movement disorders, hormonal imbalances, and neurological changes. Older, first-generation or "typical" antipsychotics tend to cause more intense side effects. Long-Term EffectsBeyond the more immediate effects, like drowsiness, tremors, and increased appetite, antipsychotics can cause effects that only appear years after treatment begins. Still, it is essential that patients understand the potential effects so they can recognize early warning signs.