So as someone who’s naturally inclined to try topical treatments before anything else, I’ve wondered whether the best wrinkle creams actually work. Vogue’s Favorite Wrinkle Creams“The effectiveness of wrinkle creams largely depends on their active ingredients,” Idriss says. “No cream is ever going to replace Botox and fillers, but wrinkle creams with the right active ingredients can help with the appearance of wrinkles over time.” “I used to tell patients that wrinkle creams offered only modest benefits,” he says. Still, for those whose skin can tolerate active ingredients, doctors remain loyal to the hallowed gold standard of antiaging skin care: retinoids.