Richard Frye, a pediatric neurologist, is one of many doctors searching for treatments that can help kids with autism. He’s studying leucovorin, an inexpensive, generic drug derived from folic acid, also known as folate or vitamin B9. Leucovorin isn’t a cure for autism, but “it could really have a substantial impact on a very good percentage of children with autism,” Frye said. Doctors can currently prescribe the drug only for autism off-label, which means repurposing a drug approved for one condition to treat another. Every Cure brought to light the work of Frye, Ramaekers, Quadros, and others on leucovorin in the treatment of autism.