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Dual transcranial electromagnetic stimulation of the precuneus boosts human long-term memory
['Ilaria Borghi', 'Lucia Mencarelli', 'Michele Maiella', 'Elias Paolo Casula', 'Matteo Ferraresi', 'Francesca Candeo', 'Elena Savastano', 'Martina Assogna', 'Sonia Bonnì', 'Giacomo Koch']
eLife: latest articles
The PC has been associated with memory engram formation and retrieval (Brodt et al., 2018; Flanagin et al., 2023; Hebscher et al., 2019).
Apart from improving long-term memory, dual iTBS + γtACS promoted a long-term increase in gamma oscillatory activity, as measured by TMS–EEG.
Gamma-band oscillatory activity drives network connectivity, allowing for information processing and binding through synchronization between distant cortical areas (Fries, 2005; Jensen et al., 2007; Miltner et al., 1999; Osipova et al., 2006).
In this perspective, the DMN has been recently identified as a new potential therapeutic target for neuromodulation in AD (Koch et al., 2025; Koch et al., 2024; Koch et al., 2022; Koch et al., 2018).
Moreover, by linking together items and concepts, long-term associative memory is essential for the construction of declarative memory and, broadly, for learning and everyday functioning.