Syracuse vs. Southern Methodist: This expert prediction is based on thousands of data-driven simulations of the game. Expert Prediction: Syracuse vs. SMULeveraging advanced data analysis, Dimers ran 10,000 simulations of Saturday’s Syracuse vs. SMU matchup at Gerald J. Ford Stadium. Syracuse vs. SMU Best BetOur top pick for this Week 6 college football matchup is Syracuse +17.5 (-110). Score Prediction: Syracuse vs. SMUDimers’ projected final score has SMU defeating Syracuse 37–20. NCAAF Week 6: Syracuse vs. SMUSaturday’s action kicks off at 3:30 p.m.