The San Francisco 49ers suffered a huge blow to their campaign after it was revealed that star quarterback Brock Purdy will be sidelined for an extended period after reaggravating his turf toe injury. https://t.co/BayozYZhPH — Ian Rapoport (@RapSheet) October 3, 2025 Expand TweetThe 25-year-old Purdy suffered the turf toe injury in Week 1 against the Seattle Seahawks. Purdy went 22-of-38 for 309 yards, two touchdowns, and two interceptions. Remember, he was dealing with that turf toe injury, came in, reported soreness, had an MRI, and the MRI revealed an aggravation of that turf toe. Backup quarterback Mac Jones started in place of Purdy on Thursday and helped the 49ers escape the Rams in overtime, 26-23.