The FDA’s latest move represents a seismic shift for gay and bisexual men as well as for the critically low U.S. blood supply. When the FDA first implemented the blood donation ban in 1983 for men who have sex with men, there were good reasons for broad regulations to ensure the safety of the blood supply. Despite the ban on blood donations from men who have sex with men, there was some small risk that failures in donor screening and blood screening protocols could lead to transmission of HIV or other diseases from blood transfusion. Modern tests and screening protocols prevent the blood of people with HIV or other diseases from getting into the U.S. blood supply. The FDA’s latest move represents a seismic shift for men who have sex with men as well as for the critically low U.S. blood supply.