These are trying times for the Lions of Orlando City SC. SpreadOrlando City SC -0.25 (-120)Nashville SC +0.25 (+100)MoneylineOrlando City SC +107Nashville SC +220Draw +270TotalOVER 3 (-110)UNDER 3 (-110)*The above data was collected on Sept. 19, 2025, and may have changed since writing. Orlando City SC vs Nashville SC Betting TrendsOrlando City SC is winless in four matches across competitions. Orlando City SC vs Nashville SC Injury ReportsOrlando CityForward Yutaro Tsukada is out with a cruciate ligament tear. Orlando City SC vs Nashville SC Predictions and PicksNashville SC's underdog odds reflect the club's fatigue following a dramatic midweek win.