The study, known as the URIC-ICU analysis, examined whether uric acid could serve as a prognostic marker in critically ill patients. The researchers highlight that uric acid reflects metabolic stress, oxidative injury, and systemic inflammation, all of which can contribute to organ damage and mortality. The findings support the use of serum uric acid as a potential biomarker for risk stratification in intensive care. While the study underscores the prognostic value of uric acid, the authors also caution that further research is needed to determine whether lowering uric acid levels can directly improve patient outcomes. 2025. doi:10.1016/j.accpm.2025.100451Keywords: Serum uric acid, intensive care unit, acute kidney injury, mortality, prognostic biomarker, FROG-ICU, URIC-ICU, Anaesthesia Critical Care & Pain Medicine