Meta-analysis of IPD showed that oxytocin decreased the risk of PPH ≥500mL (aOR 0.59; 95% CI 0.46 to 0.74) and PPH ≥1000mL (aOR 0.51; 95% CI 0.32 to 0.80). Of 10 RCTs that did not share data, seven met trustworthiness criteria while three did not. Jointly considering the results of IPD-MA and AD-MA of all RCTs meeting trustworthiness criteria, authors found that oxytocin administered in the third stage of labour significantly decreases the risk of PPH and severe PPH. Analysis of trustworthy data confirms that oxytocin significantly reduces the risk of PPH and severe PPH compared to no intervention and is associated with improved maternal safety outcomes. Twenty-one percent of RCTs did not meet predefined trustworthiness criteria, elucidating the importance of integrity assessment in evidence synthesis.