Study ObjectivesTo compare the efficacy of cognitive behavioral therapy (CBT) plus pharmacotherapy with pharmacotherapy alone for the treatment of adults with ADHD. This study was a systematic review and meta-analysis that included 6 randomized clinical trials (RCTs) comparing the treatment of adult ADHD using a combination treatment of CBT and psychopharmacotherapy (CBT + M) with M alone. ConclusionsThis systematic review and meta-analysis supports the use of CBT + M over M alone among adults with ADHD for at least 3 months. This indicates the possible need to intensify CBT treatment when there is a requirement for longer-term combined treatment among adults with ADHD. Bottom LineAmong adults with ADHD, CBT + M appears to be more beneficial than M alone at the end of treatment and during the 3-month follow-up period.