The 3 Subtypes of ApathyResearch has identified 3 neurobiologically distinct apathy subtypes, each requiring different therapeutic approaches5:1. The landmark ADMET 2 trial established methylphenidate 20 mg daily as the first evidence-based treatment for apathy in Alzheimer disease. By using validated screening tools for routine apathy detection, understanding apathy subtypes, and applying condition-specific, evidence-based pharmacological and behavioral treatment algorithms, psychiatrists can improve the quality of life of patients and their families. Distinguishing apathy from depression: a review differentiating the behavioral, neuroanatomic, and treatment-related aspects of apathy from depression in neurocognitive disorders. Mintzer J, Lanctôt KL, Scherer RW, et al; ADMET 2 Research Group.