Chronic pain affects more than 1.5 billion people worldwide and is often deeply entangled with depression and anxiety, creating a vicious cycle that amplifies suffering and impairs quality of life. “As an anesthesiologist, I frequently care for people undergoing surgery who suffer from both chronic pain and depression. The team used advanced fluorescent microscopy, a technique that uses glowing dyes to see and capture neuronal activity, to see chronic pain neurons spontaneously firing. More information:Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain, Nature Neuroscience (2025). Perelman School of Medicine at the University of PennsylvaniaProvided byPerelman School of Medicine at the University of Pennsylvania