Our findings clearly demonstrate that Long Covid brain fog should be recognized as a legitimate clinical condition. For example, drugs that suppress AMPAR activity could be a viable approach to mitigate brain fog. While further efforts will be needed to find a definitive solution for Long Covid, this work is a promising step in the right direction. “Our findings clearly demonstrate that Long Covid brain fog should be recognized as a legitimate clinical condition. In summary, the team’s findings resolve key uncertainties about the biological basis of Long Covid brain fog and may pave the way for novel diagnostic tools and effective therapies for patients suffering from this condition.