Keep reading for our Tigers vs. Guardians betting prediction. Tigers vs. Guardians Game Matchup and Betting Odds909 Detroit Tigers (-105) at 910 Cleveland Guardians (-115); o/u 7.53:00 PM ET, Thursday, October 2, 2025Progressive Field, Cleveland, OHTV: ABCTigers vs. Guardians Public Betting InformationOur MLB Public Betting Information page indicates that 68% of public bettors are currently backing the Guardians money line. Tigers vs. Guardians MLB Betting TrendsDetroit is 2-6 straight up in their last 8 games against Cleveland. Tigers vs. Guardians Betting PredictionI like Cleveland to win this elimination game at home on Thursday. Tigers vs. Guardians MLB Playoffs Betting Prediction: CLEVELAND GUARDIANS -115