Keep reading for our Padres vs. Cubs betting prediction. Padres vs. Cubs Game Matchup and Betting Odds911 San Diego Padres (-105) at 912 Chicago Cubs (-116); o/u 7.55:00 PM ET, Thursday, October 2, 2025Wrigley Field, Chicago, ILTV: ESPNPadres vs. Cubs Public Betting InformationOur MLB Public Betting Information page indicates that 58% of public bettors are currently backing the Padres money line. Padres vs. Cubs MLB Betting TrendsSan Diego is 4-2 straight up in their last 6 games against Chicago. Padres vs. Cubs Betting PredictionI like San Diego here, mainly because of their starting pitcher, Yu Darvish. Padres vs. Cubs MLB Playoffs Betting Prediction: SAN DIEGO PADRES -105