But feeling persistently cold can be a sign of more serious health concerns that you may not be aware of. Raynaud’s Disease“It’s so cold, I can’t feel my toes" is a common expression used during the Winter months. Type 2 Diabetes“Diabetes can cause nerve damage in the extremities that can make you feel cold all of the time. Hypothyroidism can slow down your metabolism, leading to a drop in your overall temperature, leaving you to feel permanently cold and especially sensitive to cold surroundings. Superdrug Online Doctor offers a Thyroid Hormone Test Kit allowing you to check your thyroid hormone levels from home.