Read our Privacy noticeThe FTSE 100 hit another record high on Wednesday, despite concerns over the US shutdown, as pharmaceutical stocks powered higher, with AstraZeneca up 11% alone. The FTSE 100 index closed up 96.00 points, 1.0%, at 9,446.43, beating its previous record close on Tuesday. The FTSE 250 ended 34.14 points higher, 0.2%, at 22,049.70, and the AIM All-Share ended up 3.24 points, 0.4%, at 786.41. AstraZeneca led the FTSE 100 and rose 11%, regaining its crown as the most valuable FTSE 100 stock from HSBC, while peers Hikma Pharmaceuticals and GSK rose 5.7% and 6.2% respectively. The biggest fallers on the FTSE 100 were: Babcock International, down 50p at 1,280p; Tesco, down 15.8p at 429.7p; Coca-Cola HBC, down 110p at 3,394p; Games Workshop, down 330p at 14,200p; and Imperial Brands, down 67p at 3,091p.