Comment on Labeled, Medicated, Misdiagnosed — Until I Rewired My Own Brain by Jason

['Michael B.', 'Michael B. Was Misdiagnosed For Years With Depression', 'Bipolar Disorder', 'Treatment Resistance. When Medications Failed', 'He Began Researching The Brain Himself. He Discovered A Neurological Condition Thalamocortical Disconnection', 'Built His Own Recovery Protocol Using Lamictal', 'Memantine', 'Neuroscience. He Now Writes To Expose The Failures Of Modern Psychiatry', 'To Show What S Possible Through Patient-Led', 'Brain-Based Healing.'] Comments for Mad In America 2025-09-12 17:00:12

Especially with high-THC strains, cannabis can modulate NMDA receptor activity and reduce unstable glutamate firing. My breakthrough came when I added Memantine—an NMDA receptor antagonist typically used in Alzheimer’s disease. Rodolfo Llinás (neuroscientist) showed that NMDA receptor dysfunction can destabilize the thalamocortical rhythm, producing the exact “disconnection” signature seen in my qEEG. Gary Parsons (neuropharmacologist) demonstrated that low-dose Memantine can stabilize NMDA receptor activity. Addressing all three major glutamate receptor subtypes—NMDA, AMPA, and kainate—restored balanced excitatory signaling, essential for re-establishing thalamocortical coherence.