A new systematic review shows that nasal spray adrenaline (via liquid or powder sprays) can be as fast or faster than injections for treating anaphylaxis, a possible needle-free alternative to EpiPen®Scientists are investigating whether nasal sprays could one day replace injections for delivering life-saving adrenaline during severe allergic reactions. Furthermore, similar or higher levels of adrenaline were detected in the blood plasma of patients who received the nasal sprays. In contrast, heart rate and blood pressure were comparable between those who received adrenaline via nasal spray and those who received an injection. Importantly, nasal sprays are more convenient and portable than injection devices, as they are more user-friendly and last longer. Nasal sprays have a shelf life of two years, whereas injections must be replaced every 12 to 18 months.