Last Updated on September 30, 2025 5:16 pm by Michael CashIllinois vs Purdue odds headline Week 6 at Ross–Ade, as the No. Illinois vs Purdue betting line — Current OddsSpread: Illinois −10.0 (+0.5 from open)Illinois −10.0 Moneyline: Illinois −380 / Purdue +290 (favorite premium added)Illinois −380 / Purdue +290 Total: 57.0 (+1.5 from open)57.0 Move: Favorite took a small push to −10; total climbed toward 57 on forecast and matchup profile. A late “out” for either would nudge the Illinois vs Purdue odds at the margins. A late “out” for either would nudge the Illinois vs Purdue odds at the margins. Expert Pick — Illinois vs Purdue odds & Buy PointsPick: Illinois −10 — The Illini’s balanced offense plus a pass-rush edge should travel.