Digital transformation is bringing new efficiency and adaptability to synthetic genomics, a field where every DNA sequence is tailored to specific research or medical needs. Within this dynamic environment, Ritesh Thakur has played a key role in streamlining how organisations produce and deliver synthetic DNA. These papers offer insights on managing the complexities of synthetic DNA production using enterprise-wide digital frameworks and digital twins to improve planning and operational efficiency. Drawing from these experiences, it's clear that the future of synthetic genomics is set to be shaped by ongoing technological innovation and the thoughtful application of digital tools. Successfully navigating this complex and highly regulated field will require a nuanced understanding of both biological processes and digital systems.