Named after the 19th-century scientist who first described abnormal masses in the lymph nodes, Hodgkin lymphoma is a cancer of the lymphatic system. Meet the expert: Alyssa Rieber, M.D., oncologist at the Texas Oncology in San Antonio and Hodgkin lymphoma survivorHere’s what you need to know about classic Hodgkin lymphoma, including who is at risk, what the signs and symptoms are, and the typical prognosis. What is Hodgkin lymphoma? The most common early symptom of Hodgkin lymphoma is swollen lymph nodes in the neck or underarms that don’t get better, says Dr. Rieber. One, in particular, is the monoclonal antibody Brentuximab, which targets a protein called CD30, located on the outside of Hodgkin lymphoma cells.