With millions of children’s lives on the line, global leaders have a once-in-a-generation chance to do something extraordinary,” said Gates. With key global health funding decisions expected before the end of the year, total funding levels could rise. The Global Fund is one of the most effective lifesaving initiatives of the 21st century. The foundation’s new pledge brings its total commitments to the Global Fund to $4.9 billion since 2002, making it one of the foundation’s largest investments. “An entire generation is alive today thanks to the world’s generosity, smart investments, and the hard work of governments and Global Fund partners,” Gates said.