The TikTok challenge nearly took the life of a teenager recently and I want to make sure that doesn’t happen to any parents here in Texas. What Is the Benadryl Challenge? It's called the Benadryl Challenge and I’m pretty sure you know what that means. It’s obviously very dangerous and parents need to talk to their kids about the dangers of taking pills that are not prescribed for them. Which is why she is encouraging all parents to speak to their kids about the dangers of the Benadryl Challenge.