Sertraline users in the UK warned against combining medication with this drinkThe juice can interact with dozens of medications, "sometimes dangerously". The NHS, on its website, advises individuals taking sertraline to avoid grapefruit juice. "Do not drink grapefruit juice while taking sertraline," warns the health body. When grapefruit juice blocks the enzyme, it's easier for the medication to pass from your gut to your bloodstream. It stated: "It's also best to avoid drinking alcohol while taking sertraline because it can stop the medicine working properly."