Despite claims of anti-vaccine activists no different than groups that used to claim vaccines cause autism, COVID-19 vaccines do not impact fecundability—the probability of conception per menstrual cycle—in female or male partners who received the Pfizer-BioNTech, Moderna, or Johnson & Johnson vaccines. The prospective study instead indicates that COVID-19 infection among males may temporarily reduce fertility— an outcome that could be avoidable through vaccination. Fecundability was also similar for male partners who had received at least one dose of a COVID-19 vaccine compared with unvaccinated male participants. Additional analyses that considered the number of vaccine doses, brand of vaccine, infertility history, occupation, and geographic region also indicated no effect of vaccination on fertility. This data supports previous research that has linked COVID-19 infection in men with poor sperm quality and other reproductive dysfunction.