[1] For people with diabetes, it’s not just drinking more fluids that makes you go to the bathroom more frequently. If blood sugar levels surpass 180 after eating, the kidneys exceed their ability to hold onto the sugar, says endocrinologist Thomas W. Donner, MD , director of the Johns Hopkins Diabetes Center in Baltimore. Increased urination, a direct result of very high blood sugar (hyperglycemia), is a hallmark symptom of diabetes and is often one of the first signs of the condition. [4]is caused by insulin deficiency, leading to ketogenesis and eventually acidosis, and it is more common in people with type 1 diabetes. HHS tends to happen when very high blood sugar causes severe dehydration.