The highest-grossing film set in Massachusetts is Ted (2012), directed by Seth MacFarlane, with a worldwide box office of $549.2 million. -boxofficemojo.comI gotta be honest - I actually forgot about this movie when I was searching for the biggest Massachusetts films! In second place, The Departed (2006), directed by Martin Scorsese, grossed $291.5 million worldwide. Jaws (1975), set on fictional Amity Island (inspired by Martha’s Vineyard), its unadjusted gross is $476.5 million, placing it below Ted. Inflation adjustment makes Jaws number one, reflecting its massive cultural and financial impact as a blockbuster pioneer.