A New Drug, and the First in its ClassLotilaner (Xdemvy/Tarsus Pharmaceuticals, Inc.) is the first and only FDA-approved drug for the treatment of demodex blepharitis. In many instances, patients diagnosed with demodex blepharitis have recalled specific triggering factors that may have caused the infestation. Demodex Blepharitis: A Comprehensive Review of the Disease, Current Management, and Emerging Therapies. Lotilaner Ophthalmic Solution, 0.25%, for the Treatment of Demodex Blepharitis: Results of a Prospective, Randomized, Vehicle-Controlled, Double-Masked, Pivotal Trial (Saturn-1). Lotilaner Ophthalmic Solution 0.25% for Demodex Blepharitis: Randomized, Vehicle-Controlled, Multicenter, Phase 3 Trial (Saturn-2).