Sickle cell research points to need for DNA testing

This article is supported by SIDA[DAR ES SALAAM, SciDev.Net] Tanzanian scientists say finding gene variants that predict a sickle cell patient’s response to drugs should pave the way for DNA testing before treatment, to improve outcomes. Sickle cell disease affects around 120 million people globally, with Africa carrying 66 per cent of the burden, according to the World Health Organization. The study analysed the DNA of 148 Tanzanian sickle cell patients to understand why some respond well to hydroxyurea while others do not. Larger, longer-term studies are needed to validate the results before genetic testing can be rolled out nationwide. “The take-home message is therefore primary prevention, premarital screening remains the most effective means of breaking the cycle of sickle cell disease,” he tells SciDev.Net.