National Football League 2025 NFL Odds Week 5: Lines, Spreads for all 14 Games Published Sep. 29, 2025 12:13 a.m. ET share facebook x reddit linkNFL Week 5 kicks off Thursday night, as the Rams host the 49ers. Here are the lines for every Week 5 matchup at DraftKings Sportsbook as of Sept. 29. Create or log in to your FOX Sports account, and follow leagues, teams and players to receive a personalized newsletter daily! What did you think of this story?