Trial: Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care. Consequently, this research recommends against routine antioxidant supplement use in men seeking fertility care. Participants included in the study were randomly assigned to either the case (combination antioxidant supplementation) or control (equivalent placebo) cohort. ConclusionsThe present study remains one of the first to explicitly test the associations between antioxidant supplementation and male fertility outcomes within a large, RCT framework. Study findings revealed that, contrary to marketing claims and popular belief, antioxidant supplementation may not improve male fertility outcomes.