CLEVELAND, Ohio — The Mega Millions jackpot has reached $497 million for its next drawing on Tuesday, Sept. 30, 2025. The numbers from the Friday, Sept. 26 drawing are 4-21-27-33-49 Mega Ball 21. The Powerball jackpot is an estimated $160 million for the Monday, Sept. 29 drawing. Drawings for Pick 3, Pick 4 and Pick 5 are twice daily, at 12:29 p.m. and 7:29 p.m. The official Ohio Lottery site offers more information on instant tickets, raffles & other lottery games.