The Buffalo Bills extended their perfect start to the 2025 season with a 31-19 win over the New Orleans Saints on Sunday afternoon at Highmark Stadium, improving to 4-0 for the first time since 2020. Buffalo jumped out to a 14-7 first-quarter lead behind a 43-yard touchdown catch-and-run from Khalil Shakir and a James Cook scoring run. Cook topped 100 rushing yards for the second time this year, finishing with 117 and his fifth touchdown of the season. More stats from the Bills 31-19 win ⬇️ pic.twitter.com/BL1eLaMAui — Buffalo Bills PR (@BuffaloBillsPR) September 28, 2025The #Saints just tried their version of the Philly Special… but the #Bills weren’t having it. pic.twitter.com/kA313CE8Gt — Ari Meirov (@MySportsUpdate) September 28, 2025Josh Allen said the Bills didn’t do themselves any favors today.