Florida State vs. Virginia Prediction: Live Odds, Stats, History and Picks – September 26, 2025

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8 Florida State Seminoles (3-0) will square off against a fellow ACC opponent, the Virginia Cavaliers (3-1) in a matchup on Friday, September 26, 2025 at Scott Stadium. Florida State vs. Virginia Favorite, Moneyline, TotalSpread favorite: Seminoles (-7)Moneyline: Seminoles (-270), Cavaliers (+220)Total: 59.5 pointsBest Florida State vs. Virginia Promo CodeHow to Watch Florida State vs. VirginiaWhen: Friday, September 26, 2025 at 7 p.m. Florida State is a perfect 1-0 against the spread when favored by 7 points or more this season. They will be up against a Florida State defense ranked 21st, allowing 248 yards per game. Florida State vs. Virginia Prediction and PickOur prediction for Florida State vs. Virginia is the Cavaliers (+220 on the moneyline) as the pick to win.