Despite global outcries and concerns, the US sanctions on Iran aimed at imposing "maximum economic pressure" on Teheran still took effect on Tuesday, three months after the United States pulled out of the landmark nuclear deal. If there is one piece of international agreements on nuclear non-proliferation that is delivering, it has to be maintained," Mogherini said. Iran accused the US of reneging on the nuclear agreement and of causing recent economic unrest in Iran. A second batch of US sanctions targeting Iran's oil sector and central bank are to be reimposed in early November. Iran's Foreign Minister Mohammad Javad Zarif said global reaction to the new sanctions showed that the US was diplomatically "isolated", but acknowledged the sanctions "may cause some disruption".