6 Best Neighborhoods & Areas to Stay in FlorenceThe Arno River runs through the heart of Florence and divides the city in two. My pick for the #1 overall best hotel in Florence, Hotel Spadai, is right on the edge of the San Giovanni neighborhood. This area is the best place for luxury travelers to stay in Florence thanks to its range of high-end hotels. Avoid Staying Directly Next to the Major MuseumsStatues at Uffizi Gallery in Florence, ItalyAs you’re deciding where to stay in Florence, steer clear of the blocks with popular museums. The best areas to stay in Florence on a budget are San Lorenzo and San Marco.