Key Takeaways Magnesium helps support energy production by activating ATP. When your energy is low or you’re getting sick more often, magnesium and vitamin C are two supplements you might consider. Vitamin C Supports Energy IndirectlyVitamin C does not directly create energy. Low vitamin C levels have been associated with fatigue and reduced physical work capacity, likely due to impaired metabolism and increased oxidative stress. High doses of vitamin C may cause gastrointestinal discomfort and, in some people, increase the risk of kidney stones.