Key Takeaways Some common dietary supplements can raise blood pressure, especially if you already have high blood pressure or heart problems. Supplements that may increase blood pressure include licorice, bitter orange, guarana, Saint-John’s-wort, caffeine, and yohimbe. Glycyrrhizic acid (GA) is a component of licorice that has been shown to raise blood pressure. However, p-synephrine can raise blood pressure. Experts recommend that people with high blood pressure limit or avoid caffeine for the following reasons:Heavy coffee intake (two or more cups per day, which is about 200 mg of caffeine) has been linked to a higher risk of heart-related death, but only in people with severely high blood pressure.