Pomegranate supplements may interact with medications, so check with a healthcare provider before use. Pomegranate supplements come in many forms, including capsules, gummies, powder, and juice that contain pomegranate extract sourced from the seed, juice, peel, leaf, and flower. How Pomegranate Supplements Support HealthPomegranate supplements show promise in offering health benefits, including:Improving inflammation: Pomegranates contain flavonoids (plant compounds) that have antioxidant properties. Overall, pomegranate juice and pomegranate extract are considered safe. There is little evidence on whether drinking pomegranate juice or ingesting pomegranate extract is harmful during pregnancy or breastfeeding.