A surprising number of major stars appeared in House M.D., with several only just starting their acting careers. Meat LoafMeat Loaf on House Season 5, Episode 20, “Simple Explanation”Meat Loaf’s appearance in House season 5’s “Simple Explanation” remains one of the most emotionally devastating guest roles. Amanda SeyfriedHouse Detox Amanda SeyfriedAmanda Seyfried’s House season 1 appearance in “Detox” is easy to overlook, but her performance as Pam is surprisingly compelling. Lin-Manuel MirandaHouse at Alvie's court dateLin-Manuel Miranda’s turn as Juan “Alvie” Alvarez in House season 6’s “Broken” is one of the show's most unexpected and memorable guest performances. Cynthia NixonAnica looking confused in the House episode DeceptionCynthia Nixon’s guest role in season 2’s “Deception” is one of House M.D.’s most quietly tragic performances.