APPLETON (NBC 26) — A fire caused major damage to an Appleton home on Thursday before first responders jumped into action. Smoke was coming from the roof, but firefighters were able to bring it under control within 15 minutes. No one was injured, firefighters say. The Appleton Fire Department would like to remind residents to know two ways out of every room. It is important to know two ways out in case one is blocked or dangerous.