This “long overdue” update expands the pools of patients eligible for thrombolysis and thrombectomy, and tackles pediatric stroke. A new guideline on the early management of acute ischemic stroke released this week by the American Heart Association/American Stroke Association (AHA/ASA) revamps guidance on prehospital care, use of thrombolysis and thrombectomy, management of blood pressure and glucose, pediatric stroke, and more. It was published online this week in Stroke and will be presented and discussed next week at the International Stroke Conference in New Orleans, LA. There is a new class 1 recommendation, based on trials like B_PROUD and BEST-MSU, to use mobile stroke units to transport and manage patients who have suspected acute ischemic stroke and are eligible for thrombolytics to improve functional outcomes. Thrombolysis and Thrombectomy ExpandRecommendations around use of IV thrombolysis and mechanical thrombectomy have been updated to refine and expand eligibility.