Keeping your desktop computer fan clean is essential for keeping your system cool and efficient. Here's how you can clean your desktop computer fan effectively, without any fuss. A screwdriver set is essential to open the computer case. Safety first Power down and unplug your computer Before you start cleaning, always power down your computer and unplug it from the wall. AdvertisementAccessing internal components Open the computer case carefully Once powered down and unplugged, use a screwdriver to carefully remove screws holding the computer case together.