Using male Sprague-Dawley rats, researchers created a small incision on the dorsum (back) to model wound-related pain, a condition that remains common and often poorly managed in clinical settings. By the eighth day after surgery, rats were given a single dose of CBD at 3, 10, or 30 mg/kg. The researchers found that the lowest dose, 3 mg/kg, partially reduced mechanical hypersensitivity directly at the wound site. According to the researchers, these findings suggest that CBD may produce antinociceptive effects in incision-related wound pain through localized and region-specific interactions within the endocannabinoid system, rather than broad systemic changes. The study concludes that CBD shows measurable pain-reducing effects in this model of wound-related pain and warrants further investigation into its mechanisms of action.